|
Molecular characteristics of normal and
leukemia stem cells
Foz do Iguazu, Brazil, 25-28 July 2007
Organisers: George Daley, John Goldman,
Catriona Jamieson, Junia Melo,
Nance Nardi, Peter Quesenberry, Lucia
Silla, Daniel Tabak, Irv Weissman, Marco
Zago
OUTLINE OF PROGRAM – 14 March 2007
Wednesday, 25 July 2007
|
18.00 – 21.00 |
Arrival and welcome
reception |
Thursday, 26 July 2007
|
08.30 – 08.35 |
Welcome
|
|
08.35 – 09.05 |
Keynote 1 Irv Weissman
|
|
09.05 – 10.30 |
Session 1 – Stem cell
properties
Connie Eaves
‘New basic hematopoietic stem cell data
and CML stem cell SAGE data and some
other molecular manipulation results’
Amy Wagers
‘Leaving the niche: regulators of stem
cell migration’
John Dick
‘Cancer initiating cells: from leukemia
to solid tumors’
Ken Kaushansky
Growth factors that influence the
expression of vital hematopoietic stem
cell transcription factors
Mariusz Rataczak
Session 1 ‘Physiological and
pathological consequences of very small
embryonic like (VSEL) stem cells in
adult bone marrow’
Marco Zago
TBA
|
|
11.00 – 13.00
|
Session 2 - Self renewal
pathways - Wnt/b-catenin
Catriona Jamieson
‘Epiigenetic dysregulation of leukemic
stem cell self-renewal’
Tannishtha Reya
‘Wnt signaling in stem cells and cancer”
Roel Nusse
Wnt proteins as self-renewing stem cell
factors
Tony Green
‘JAK2 mutations in the BCR-ABL negative
MPDs’
|
|
14.00 – 16.00 |
Session 3 – Self renewal
pathways – BMI-1, alpha catenin
Maarten van Lohuizen
See email for choice of presentations
Sean Morrison
‘Stem cell self-renewal, cancer cell
proliferation, and ageing’
Michael Clarke
TBA
Len Zon
Regulation of self renewal by
prostaglandins E
Junia Melo
‘Bmi-1 as a prognostic marker in CML’
|
|
16.30 – 18-30 |
Session 4 – Stroma/Stem
Cell Niche
Harvey Lodish
‘Purification and expansion of
hematopoietic stem cells based on
proteins expressed by a novel stromal
cell population’
Andreas Trumpp
‘The role of Myc genes in HSC
self-renewal and niche dependent
differentiation’
Mariusz Rataczak (2) ‘The crucial role
of the complement system in trafficking
and homing of hematopoietic stem cells’
David Traver
Ontogeny of hematopoiesis in the
zebrafish embryo
|
Friday, 27 July 2007
|
08.30 – 09.00 |
Keynote 2 - Sean Morrison
|
|
09.00 – 10.30 |
Session 5 – LSC pathways –
NOTCH, others
Tom Look
TBA
Garry Gilliland
The role of FoxO transcription factors
in normal and malignant hematopoiesis
Richard van Etten
‘Targeting the engraftment of Ph+
leukemia stem cells’
|
|
11.00 –14.00 |
Session 6 - Transcriptional
Regulation eg PU.1, junB
Dan Tenen
‘Transcription factors in normal and
leukemic stem cells’
Hanno Hock
‘The transcriptional control of
childhood leukemia’
Emmanuelle Passegue
TBA
Afternoon and evening free
|
Saturday, 28 July 2007
|
08.00 – 09.00 |
Session 7 – Genomic
instability
Tomasz Skorski
TBA
Dean Felsher
TBA
Peter Lansdorp
‘Mutations in telomerase genes and stem
cell exhaustion’
|
|
09.00 –10.00 |
Session 8 – LSC pathways
(2)
Giulio Superti-Furga
‘Molecular characterization of targets
of CML kinase inhibitors’ or
‘The Bcr-Abl molecular machine and other
proteins as targets of kinase inhibitors’
or
‘Molecular pharmacology of Bcr-Abl
revised by proteomics studies’
Ihor Lemischka
‘Dissecting cell fate regulation in stem
cells’
Peter Quesenberry
‘The stem cell continuum and phenotypic
lability’
Jean Wang
‘Innate resistance of CML stem cells to
Imatinib’
Bob Lowenberg
‘Expression profiling as a tool to
resolve genetic stem cell heterogeneity
in acute leukemia’
|
|
10.00 – 10.30 |
Keynote 3 - John Goldman or George Daley [Imatinib] |
|
10.30 – 12.00 |
Session 9 – Second
generation TKIs
Neil Shah
‘Dasatinib – mechanisms of resistance’
Frank Giles
‘Nilotinib – mechanisms of resistance’
|
|
14.00 – 16.00 |
Session 10 – Third
generation TKIs and JAK2 kinase
inhibitors
Jorge Cortes
‘Bosutinib (SKI-606) – preclinical and
clinical studies’
Frank Giles
‘MK-0457 – preclinical and clinical
studies’
Jorge Cortes
‘INNO-406 - preclinical and clinical
studies’
Andrew Wilks
TBA
|
|
16.30 – 18.30 |
Session 11 - Response
definitions and therapeutic strategies
Tim Hughes
‘Predicting responses to TKI’
John Goldman
‘Monitoring response to therapy’
Armand Keating
‘Decisions in CML’
|
|
19.30 –
22.00 |
Speakers dinner |
Sunday 29 July 2007
Transfer to Gramado or Sao Paulo
|
